Recent attempts at RNAi-mediated P-glyco
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Meysam Abbasi; Afsaneh Lavasanifar; Hasan UludaΛ
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Article
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2011
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John Wiley and Sons
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English
β 286 KB
Multidrug resistance (MDR) is among the major mechanisms leading to failure in chemotherapy of cancer patients. The ATPβbinding cassette proteins are major contributors to MDR, involved in the active efflux of xenobiotics out of cancer cells. Among them, Pβglycoprotein (Pβgp) is the most dominant pr