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In vivo Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Efficient Delivery of StealthTM RNAi

✍ Scribed by Hong Xiao; Zhuo Wu; Hong Shen; Ai-Lan Luo; Yu-Fei Yang; Xiao-Bo Li; Dong-Ya Zhu


Book ID
111316552
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
645 KB
Volume
103
Category
Article
ISSN
1742-7835

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Multidrug resistance (MDR) is among the major mechanisms leading to failure in chemotherapy of cancer patients. The ATP‐binding cassette proteins are major contributors to MDR, involved in the active efflux of xenobiotics out of cancer cells. Among them, P‐glycoprotein (P‐gp) is the most dominant pr