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In vivo restoration of the biological activity of transforming DNA inactivated by 32P disintegration

✍ Scribed by Rosenthal, Peter N.; Fox, Maurice S.

Book ID
122064620
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
299 KB
Volume
50
Category
Article
ISSN
0022-2836

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## Abstract There is significant human exposure to polycyclic aromatic hydrocarbons (PAHs), many of which are potent carcinogens in laboratory animals and are suspected human carcinogens. The PAHs are bioactivated by cytochrome P450 (CYP)1A1/1B1 enzymes to reactive intermediates that bind to DNA, a