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In vivo repopulation of cytoplasmically gene transferred hematopoietic cells by temperature-sensitive mutant of recombinant Sendai viral vector

✍ Scribed by Kumi Yoshida; Yoshikazu Yonemitsu; Sakura Tanaka; Shuro Yoshida; Satoko Shibata; Haruhiko Kondo; Shinji Okano; Fumihiko Ishikawa; Koichi Akashi; Makoto Inoue; Mamoru Hasegawa; Katsuo Sueishi

Book ID: 116295414
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 423 KB
Volume: 361
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2007.07.111

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## Abstract ## Background Adeno‐associated virus (AAV) vectors have been shown to correct a variety of mutations in human cells by homologous recombination (HR) at high rates, which can overcome insertional mutagenesis and transgene silencing, two of the major hurdles in conventional gene addition