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In vivo receptor occupation by benzodiazepines and correlation with the pharmacological effect

✍ Scribed by Theodora Duka; Volker Höllt; Albert Herz

Book ID
118865087
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
562 KB
Volume
179
Category
Article
ISSN
0006-8993

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In vivo benzodiazepine receptor occupanc
In vivo benzodiazepine receptor occupancy by CL 218,872 visualized by positron emission tomography in the brain of the living baboon: modulation by GABAergic transmission and relation with anticonvulsant activity
✍ V. Sayette; C. Chavoix; E. Brouillet; P. Hantraye; M. Kunimoto; M. Khalili-Varas 📂 Article 📅 1991 🏛 Springer-Verlag 🌐 English ⚖ 611 KB

In vivo benzodiazepine receptor occupancy by increasing doses of CL 218,872 has been evaluated in the baboon Papio papio, using (11C) RO 15-1788 as specific radioligand and positron emission tomography as external detection system. Although BZR heterogeneity has been previously demonstrated in the b