In vivo quantitative three-dimensional motion mapping of the murine myocardium with PC-MRI at 17.6 T
✍ Scribed by Volker Herold; Philipp Mörchel; Cornelius Faber; Eberhard Rommel; Axel Haase; Peter M. Jakob
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 351 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
This work presents a method that allows for the assessment of 3D murine myocardial motion in vivo at microscopic resolution. Phase‐contrast (PC) magnetic resonance imaging (MRI) at 17.6 T was applied to map myocardial motion in healthy mice along three gradient directions. High‐resolution velocity maps were acquired at three different levels in the murine myocardium with an in‐plane resolution of 98 μm, a slice thickness of 0.6 mm, and a temporal resolution of 6 ms. The applied PC‐MRI method was validated with phantom experiments that confirmed the correctness of the method with deviations of <1.7%. Myocardial in‐plane velocities between 0.5 cm/s and 2.2 cm/s were determined for the healthy murine myocardium. Through‐plane velocities of 0.1–0.83 cm/s were measured. Velocity data was also used to calculate the myocardial twist angle during systole at different slices in the short‐axis view. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.