𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo quantitative proton MRSI study of brain development from childhood to adolescence

✍ Scribed by Alena Horská; Walter E. Kaufmann; Larry J. Brant; Sakkubai Naidu; James C. Harris; Peter B. Barker

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
360 KB
Volume
15
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose

To quantify regional variations in metabolite levels in the developing brain using quantitative proton MR spectroscopic imaging (MRSI).

Materials and Methods

Fifteen healthy subjects three to 19 years old were examined by in vivo multislice proton MRSI. Concentrations of N‐acetyl aspartate (NAA), total choline (Cho), total creatine (Cr), and peak area ratios were determined in selected frontal and parietal gray and white matter regions, basal ganglia, and thalamus.

Results

In cortical gray matter regions, the ratio of NAA/Cho increased to a maximum at 10 years and decreased thereafter (P = 0.010). In contrast, in white matter, average ratios NAA/Cho increased linearly with age (P = 0.045). In individual brain regions, age‐related changes in NAA/Cho were found in the putamen (P = 0.044). No significant age‐related changes in NAA, Cho, Cr, or other metabolite ratios could be determined.

Conclusion

Consistent with recent studies using other structural and functional neuroimaging techniques, our data suggest that small but significant changes occur in regional cerebral metabolism during childhood and adolescence. Non‐linear age related changes of NAA/Cho in frontal and parietal areas, resembling previously reported age related changes in rates of glucose utilization and cortical volumes, may be associated with dendritic and synaptic development and regression. Linear age‐related changes of NAA/Cho in white matter are also in agreement with age‐related increases in white matter volumes, and may reflect progressive increases in axonal diameter and myelination. J. Magn. Reson. Imaging 2002;15:137–143. Published 2002 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Using pattern analysis of in vivo proton
Using pattern analysis of in vivo proton MRSI data to improve the diagnosis and surgical management of patients with brain tumors
✍ M. C. Preul; Z. Caramanos; R. Leblanc; J. G. Villemure; D. L. Arnold 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 680 KB

We have used pattern analysis of proton magnetic resonance spectroscopic imaging ( 1 H MRSI) data in a variety of situations related to the clinical management of patients with brain tumors and other cerebral spaceoccupying lesions (SOLs). Here, we review how 'leave-one-out' linear discriminant anal

Growth and development of human muscle:
Growth and development of human muscle: A quantitative morphological study of whole vastus lateralis from childhood to adult age
✍ Dr. Jan Lexell; Dr. Michael Sjöström; Ms. Ann-Sofie Nordlund; Dr. Charles C. Tay 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 739 KB

The mechanisms underlying the increase in volume of muscle tissue, and the functional development of muscle fibers from childhood through adolescence to adult age, have been studied. Cross sections of autopsied whole vastus lateralis muscle from 22 previously physically healthy males, 5 to 37 years

Development of social problem-solving st
Development of social problem-solving strategies and changes in aggressive behavior: A 7-year follow-up from childhood to late adolescence
✍ Liisa Keltikangas-Järvinen; Laura Pakaslahti 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 2 views

The aim of this study was to predict a stability of aggressive behavior on the basis of social problem-solving strategies. Subjects were a total of 120 children, but complete follow-up data were available only in 47 cases. Their aggressive behaviors were peer rated, and problem-solving strategies we