In vivo quantification of T1ρ using a multislice spin-lock pulse sequence

✍ Scribed by Andrew J. Wheaton; Arijitt Borthakur; J. Bruce Kneeland; Ravinder R. Regatte; Sarma V. S. Akella; Ravinder Reddy

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 411 KB
• Volume: 52
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.20268

✦ Synopsis

Abstract

A multislice spin‐lock (MS‐SL) pulse sequence is implemented on a clinical scanner to acquire multiple images with spin‐lock‐generated contrast of the knee joints of six healthy human subjects. The MS‐SL sequence produces images with T~1ρ~ contrast with an additional factor of intrinsic T~2ρ~ weighting, which hinders direct measurement of T~1ρ~. A method is presented to compensate the MS‐SL‐generated data with regard to T~2ρ~ in an effort to accurately calculate multislice T~1ρ~ maps in a feasible experimental time. The T~2ρ~‐compensated multislice T~1ρ~ maps produced errors in the measurement of T~1ρ~ in healthy patellar cartilage of ∼5% compared to the gold standard measurement of T~1ρ~ acquired with single‐slice spin‐lock pulse sequence. The MS‐SL sequence has potential as an important clinical tool for the acquisition of multislice T~1ρ~‐weighted images and/or quantitative multislice T~1ρ~ maps. Magn Reson Med 52:1453–1458, 2004. © 2004 Wiley‐Liss, Inc.