𝔖 Bobbio Scriptorium
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In Vivo proton spectroscopy and spectroscopic imaging of {1-13C}-g1ucose and its metabolic products

✍ Scribed by Peter C. M. Van Zijl; A. Scott Chesnick; D. Despres; Chrit T. W. Moonen; J. Rhiz-Cabello; P. Van Gelderen

Book ID
102955822
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
755 KB
Volume
30
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Metaibolism of {1−^13^C}‐glucose was studied in situ in cat brain usinig gradient‐enhanced proton‐detected heteronuclear spectroscopy. Proton detection of {1−^13^C}‐glucose, {3−^13^C}−lactaite, 4−{^13^C}‐glutamine, 4−{^13^C}‐glutamate and the combined signals 2−{^13^C}‐glutamate/glutamine and 3−(^13^C}‐glutamate/glutamine was achieved, despite the fact that some of the associated proton resonances are close to the water signal. Two‐dimensional {^1^H‐^13^C}‐spectra demonstrate the possibility of in situ spectral assignment with ^1^H sensitivity and ^13^C resolution. Spectroscopic images of glucose and its metabolic products were also acquired, showing the possibility to study spatial dependence of metabolism.

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