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In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage

✍ Scribed by Manfred Brauer; Rheal A. Towner; Ian Renaud; Edward G. Janzen; David L. Foxall

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 694 KB
Volume: 9
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910090208

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✦ Synopsis

Proton magnetic resonance imaging and localized NMR spectroscopy were used to study the rat liver in situ. Respiratory gating was used in both the imaging and the localized spectroscopy studies to control for the movement of the upper abdomen of the rat during breathing. After administration of carbon tetrachloride, bromotrichloromethane, or halothane, localized regions of high proton signal intensity were observed in the NMR images of the liver. Localized (VOSY) proton NMR spectra from within these regions indicated that the increase in a signal intensity was due to a longer Tz relaxation time for the water resonance, indicating acute edema in the region of tissue damage. o 1989 Academic Press, Inc.

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