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In vivo proton magnetic resonance spectroscopy detection of human alcohol tolerance

✍ Scribed by Talc-Ming Chiu; Jack H. Mendelson; Bryan T. Woods; Siew Koon Teoh; Lisi Levisohn; Nancy K. Mello

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
693 KB
Volume
32
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Alcohol tolerance was ascertained with in vivo proton magnetic resonance spectroscopy (MRS) in men who regularly consumed either large (10–20 drinks/week) or small (2–4 drinks/week) amounts of beverage alcohol. Brain ethanol concentrations were determined by MRS, and blood ethanol levels were measured by gas chromatography after controlled ethanol administration (0.8 g/kg). Brain‐blood ethanol concentration ratios for heavy drinkers were significantly greater than ratios for occasional drinkers (P < 0.002). Inasmuch as ethanol tolerance covaries with the severity of dependence, MRS procedures may facilitate our understanding of alcohol tolerance and treatment of alcoholism.

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