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In vivo pharmacological properties of RPR100893, a novel non-peptide antagonist of the human NK1 receptor

✍ Scribed by S.M. Moussaoui; F. Montier; A. Carruette; V. Fardin; A. Floch; C. Garret

Book ID: 113237458
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 132 KB
Volume: 26
Category: Article
ISSN: 0143-4179
DOI: 10.1016/0143-4179(94)90219-4

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## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high