In vivo NMR spectroscopy in patients with phenylketonuria: Clinical significance of interindividual differences in brain phenylalanine concentrations
✍ Scribed by J. Weglage; H. E. Möller; D. Wiedermann; S. Cipcic-Schmidt; J. Zschocke; K. Ullrich
- Book ID
- 110222801
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 92 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0141-8955
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High-resolution proton NMR spectra of normal human brain in vivo have been obtained from selected 27-and 64-ml volumes-of-interest (VOI) localized in the insular area, the occipital area, the thalamus, and the cerebellum of normal volunteers. Localization was achieved by stimulated echo (STEAM) sequ
At the high field strength of 7 T, __in vivo__ spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur