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In vivo mutagenicity of benzo[f]quinoline, benzo[h]quinoline, and 1,7-phenanthroline using the lacZ transgenic mice

โœ Scribed by Katsuya Yamada; Takayoshi Suzuki; Arihiro Kohara; Makoto Hayashi; Takaharu Mizutani; Ken-Ichi Saeki


Book ID
116758777
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
120 KB
Volume
559
Category
Article
ISSN
1383-5718

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Big Blue@ (BB) and generic B6C3F1 mice were given one to three i.p. injections of 50 mg/kg benzo[a]pyrene (B[a]P) in DMSO every other day to achieve cumulative doses of 50 to 150 mg/kg. Three weeks after treatment, the mutation frequency at the endogenous hprt gene and lac/ transgene was measured in