✦ LIBER ✦

In vivo molecular imaging

✍ Scribed by R.J. Gillies

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 314 KB
Volume: 87
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.10450

No coin nor oath required. For personal study only.

✦ Synopsis

The relatively young field of molecular imaging is focused on the visualization of molecular phenotypes in whole organisms. This is achieved using imaging systems based on radionuclides, nuclear magnetic resonance, ultrasound, or the visible-IR region of the optical spectrum. Molecularly defined contrast in these modalities is generated by exogenous probes of the endogenous proteome, or through transgenes. Examples of exogenous probes include those that are transported and trapped (glucose, nucleoside analogs), those directed against extracellular receptors (somatostatin, opioid, melanotropin), and those activated by extracellular proteases. Transgenes that have been used in molecular imaging include the above receptors, non-mammalian enzymes that trap pro-drugs (HSV-tk, yeast CD), and optical reporter proteins (luciferase, fluorescent proteins). Cutting edge technologies in this field include in vivo assays for protein-protein interactions, and in vivo assays for mRNA expression patterns. The number of degrees of freedom in designing new agents is daunting, and advancements in this field will require a significant participation from molecular and cellular biochemists.

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