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In vivo modulation of rat liver acyl-coenzyme A:cholesterol acyltransferase by phosphorylation and substrate supply

✍ Scribed by Keith E. Suckling; Eduard F. Stange; John M. Dietschy

Book ID
115914560
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
395 KB
Volume
159
Category
Article
ISSN
0014-5793

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Acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors are currently in clinical development as potential lipid-lowering and antiatherosclerotic agents. We investigated the effect of avasimibe (Cl-1011), a novel ACAT inhibitor, on bile acid synthesis and cholesterol 7␣hydroxylase in cultured