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In vivo methotrexate selection of murine hemopoietic cells transduced with a retroviral vector for Gaucher disease

✍ Scribed by Havenga, M J E; Valerio, D; Hoogerbrugge, P; van Es, H H G


Book ID
110038544
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
132 KB
Volume
6
Category
Article
ISSN
0969-7128

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## Abstract ## Background Hematopoietic stem‐cell‐directed gene transfer has achieved limited success in transducing clinically relevant levels of target cells. The expansion of gene‐modified cells is one way to circumvent the problem of inefficient transduction with current vectors. To this end,