Several topical spray-on bandages were developed and studied to determine a suitable method for evaluating the effectiveness of this group of products. Several formulations were prepared using neomycin sulfate and triclosan. Ethylcellulose and polyamide resins served as the film-forming agents, while tributyl citrate and bexadecyl alcohol were chosen as the plasticizers. Neomycin sulfate and triclosan preparations were evaluated using an in uiuo method. Standardized, contaminated wounds in guinea pigs served as the testing system. The inflammatory response of the wounds was evaluated using several indexes including skin temperature, degree of induration, and presence of pus. The results indicate that neomycin sulfate and triclosan were released from their formulations. The spray-on bandages reduced the degree of infection about the wound. No difference was noted between the results obtained using either film former.
Keyphrases Spray-on bandages containing anti-infectives (neomycin sulfate and tric1osan)-determination of in uiuo effectiveness, guinea pigs Anti-infective spray-on bandages (neomycin sulfate and tric1osan)-determination of in uiuo effectiveness, guinea pigs Aerosol anti-infectives (neomycin sulfate and triclosan)-determination of in uiuo effectiveness of spray-on bandages, guinea pigs *