Ethyldelta-gtetrahydrocPnnabinol (ethyldelta-8-THC) and ethyldelta-9-THC were synthesized by condensation of 5-ethyl-l,3dihydroxybenzene and lS-cis-verbenol. The two cannabiaoids were administered to male Charles River CD-1 mice and hepatic metabolites were extracted with ethyl acetate and isolated
In vivo metabolism of (+)-trans-Delta-9-tetrahydrocannabinol in the mouse
β Scribed by D. J. Harvey
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 480 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1076-5174
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## Abstract We report the first demonstration of EPR spectroscopy to study free radical reactions in live mice and excised muscle tissue resulting from the metabolism of nitrosobenzene. A broad threeβthe EPR spectrum (a~N~ = 11.6 G) appeared in the buttocks region of a mouse place in an Lβband loop