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In vivo key role of reactive oxygen species and NHE-1 activation in determining excessive cardiac hypertrophy

✍ Scribed by Oscar H. Cingolani; Néstor G. Pérez; Irene L. Ennis; María C. Álvarez; Susana M. Mosca; Guillermo R. Schinella; Eduardo M. Escudero; Gloria Cónsole; Horacio E. Cingolani


Publisher
Springer
Year
2011
Tongue
English
Weight
607 KB
Volume
462
Category
Article
ISSN
0031-6768

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## Abstract Using spontaneously hypertensive and aortic banded rats, we have shown that expression of myocardial osteopontin, an extracellular matrix protein, coincides with the development of heart failure and is inhibited by captopril, suggesting a role for angiotensin II (ANG II). This study tes