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In vivo investigation of the NMDA/NOS/CGMP pathway during aging in the hippocampus and cerebellum of freely-moving rats

โœ Scribed by E. Fedele; A. Conti; M. Raiteri

Book ID
119179523
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
143 KB
Volume
31
Category
Article
ISSN
1043-6618

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In vivo effects of phosphodiesterase inh
In vivo effects of phosphodiesterase inhibition on basal cyclic guanosine monophosphate levels in the prefrontal cortex, hippocampus and cerebellum of freely moving rats
โœ Antonella Marte; Olimpia Pepicelli; Anna Cavallero; Maurizio Raiteri; Ernesto Fe ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 137 KB

## Abstract We have characterized the various phosphodiesterases (PDE) that degrade cyclic GMP in the prefrontal cortex, hippocampus, and cerebellum using the microdialysis technique to measure in vivo extracellular cyclic GMP in awake rats. The following PDE blockers were used (100 and 1,000 ฮผM):