In vivo intravascular laser photodynamic therapy in rabbit atherosclerotic lesions using a lateral direction fiber
✍ Scribed by Katoh, Tomitsugu; Asahara, Takayuki; Naitoh, Yuuichi; Nakajima, Hitoshi; Usui, Mikio; Rakue, Hiroyuki; Amemiya, Tadashi; Miyagi, Manabu; Ibukiyama, Chiharu
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 960 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0196-8092
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✦ Synopsis
Background and objective:
This study was performed to evaluate the possibility of inducing regression of atherosclerotic foci by photodynamic therapy (pdt) using hematoporphyrin derivative (hpd).
Study design/materials and methods:
Atherosclerotic rabbits were divided into four groups: a (n = 6) and c (n = 6) were given 5 mg/kg of hpd intravenously; groups b (n = 4) and d (n = 4) were not. twenty-four hours after hpd administration, the aortae of groups a and b were exposed to 200 mw output argon dye laser beam at 630 nm for 10 minutes; groups c and d were exposed to 400 mw for 5 minutes. three rabbits from groups a and c and two rabbits from groups b and d were sacrificed immediately after laser photoradiation, being named groups a 0, c 0 and groups b 0, d 0, respectively. groups a 7, c 7, and groups b 7, d 7 were sacrificed 7 days after the photoradiation.
Results:
In groups a 7 and c 7, most intimal cells and endothelial cells had become necrotic and disappeared, and a loss of intima was observed. no such changes were found in groups b 7, d 7.
Conclusion:
The above data suggest that pdt caused effective regression of the atherosclerotic lesions.