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in vivo inhibition of PC-3 human androgen-independent prostate cancer by a targeted cytotoxic bombesin analogue, AN-215

✍ Scribed by Artur Plonowski; Attila Nagy; Andrew V. Schally; Baodong Sun; Kate Groot; Gabor Halmos

Book ID
111697622
Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
108 KB
Volume
88
Category
Article
ISSN
0020-7136

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πŸ“œ SIMILAR VOLUMES

Targeted chemotherapy with cytotoxic bom
Targeted chemotherapy with cytotoxic bombesin analogue AN-215 inhibits growth of experimental human prostate cancers
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## Abstract We developed a powerful cytotoxic analogue of bombesin AN‐215, in which the bombesin (BN)‐like carrier peptide is conjugated to 2‐pyrrolino doxorubicin (AN‐201). Human prostate cancers express high levels of receptors for BN/gastrin releasing peptide (GRP) that can be used for targeted

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## Abstract Bombesin (BN) and gastrin‐releasing peptide (GRP) have been shown to stimulate the growth of human prostate cancer __in vivo__ and __in vitro__ by mechanisms initiated by binding of the peptide to BN/GRP receptor (GRPR). GRPR is overexpressed in a variety of human cancers, including hum