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In vivo imaging of siRNA delivery and silencing in tumors

✍ Scribed by Medarova, Zdravka; Pham, Wellington; Farrar, Christian; Petkova, Victoria; Moore, Anna

Book ID: 109932919
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 456 KB
Volume: 13
Category: Article
ISSN: 1078-8956
DOI: 10.1038/nm1486

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## Abstract In vivo gene silencing using RNAi plays an important role in target validation and is advancing towards the development of RNAi‐based therapeutics. RNAs were thought to have just two broad functions in cells as messenger RNAs (mRNAs) and ribosomal RNAs, but recently the relevance of mic