✦ LIBER ✦

In vivo imaging of hematopoietic stem cells and their microenvironment

✍ Scribed by Cristina Lo Celso; Juwell W. Wu; Charles P. Lin

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 395 KB
Volume: 2
Category: Article
ISSN: 1864-063X
DOI: 10.1002/jbio.200910072

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In this review we provide a description of the basic concepts and paradigms currently constituting the foundations of adult stem cell biology, and discuss the role that live imaging techniques have in the development of the field. We focus on live imaging of hematopoietic stem cells (HSCs) as the basic biology and clinical applications of HSCs have historically been at the forefront of the stem cell field, and HSC are the first mammalian tissue stem cells to be visualized in vivo using advanced light microscopy techniques. We outline the current technical challenges that remain to be overcome before stem cells and their niche can be more fully characterized using the live imaging technology. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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