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In vivo imaging of epileptic activity using 2-NBDG, a fluorescent deoxyglucose analog

✍ Scribed by Vassiliy Tsytsarev; Konstantin I. Maslov; Junjie Yao; Archana R. Parameswar; Alexei V. Demchenko; Lihong V. Wang

Book ID
113729000
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
734 KB
Volume
203
Category
Article
ISSN
0165-0270

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Phospholipase substrate analogs containing both a fluorescent BODIPY group and a quenching 2,4-dinitrophenyl (DNP) group were synthesized. They showed little fluorescence, but upon hydrolysis became fluorescent as the quenching group was removed. Two substrates were phosphatidylethanolamine analogs