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In vivo imaging and specific targeting of P-glycoprotein expression in multidrug resistant nude mice xenografts with [125I]MRK-16 monoclonal antibody

✍ Scribed by Andrew M. Scott; Eddie Rosa; Bippin M. Mehta; Chaitanya R. Divgi; Ronald D. Finn; June L. Biedler; Takashi Tsuruo; Hovannes Kalaigian; Steven M. Larson


Book ID
116172000
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
823 KB
Volume
22
Category
Article
ISSN
0969-8051

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## Abstract Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX to serve as a target for cancer diagnostics and therapy. Here we evaluated targeting properties and pharmacokin