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In vivo homologous regulation of μ-opioid receptor gene expression in the mouse

✍ Scribed by Fatima Sehba; Alokesh Duttaroy; Sukrut Shah; Billy Chen; Joanne Carroll; Byron C Yoburn

Book ID
119414186
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
197 KB
Volume
339
Category
Article
ISSN
0014-2999

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In vivo regulation of μ-opioid receptor
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✍ Alokesh Duttaroy; Byron C. Yoburn 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB

Chronic in vivo treatment with the opioid agonist etorphine downregulates mu-opioid receptor density, produces tolerance, and regulates gene expression in the mouse. After cessation of treatment, there is an increase in mu-opioid receptor mRNA level associated with the recovery of mu-opioid receptor