In vivo gallbladder bile diffusion coefficient measurement by diffusion-weighted echo planar imaging in hamster fed normal and lithogenic diets

✍ Scribed by Bernard Tiffon; Michel Parquet; Sandrine Dubrac; Claude Lutton; Andreas Volk

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 138 KB
• Volume: 43
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/1522-2594(200006)43:6<854::aid-mrm11>3.0.co;2-e

✦ Synopsis

It is shown that in vivo measurement of bile water apparent diffusion coefficient (ADC) by diffusion-weighted echo-planar imaging (EPI) in hamster gallbladder is possible providing motion artifact-free ADC values. These ADC values are used to estimate bile viscosity variation induced by normal diets, cholesterol gallstone-inducing diets, and an antilithiasic drug, and to determine if a link exists between bile viscosity and cholesterol gallstone formation. Measurements were performed at 4.7 T with respiratory triggering in five groups of hamsters fed a commercial (RC) or a semisynthetic (SSD) diet, a SSD containing 0.2% hyodeoxycholic acid (SSD؉HDC) and two lithogenic diets (LD5, LD10). ADC decreased significantly in LD10 (2.15 ؎ 0.07 ؋ 10 ؊3 mm 2 s ؊1 ) and SSD؉HDC (2.03 ؎ 0.04) compared to RC (2.40 ؎ 0.05) but not in the most lithogenic LD5 diet (2.33 ؎ 0.06). No direct relationship was found between bile viscosity and gallstone incidence; however, viscosity seems to be related to lipid contents of diets. Magn Reson Med 43:854 -859, 2000.