𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo F-19 chemical shift imaging with FTPA and antibody-coupled FMIQ

✍ Scribed by Hideyuki Mishima; Tetsurou Kobayashi; Masahiro Shimizu; Yasuhiro Tamaki; Masashi Baba; Takashi Shimano; Soichi Itoh; Masaru Yamazaki; Norio Iriguchi; Mutsumasa Takahashi; Takesada Mori

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
488 KB
Volume
1
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A mixture of perfluoromethyldecahydroisoquinoline (FMIQ) emulsion coupled with anti‐CEA (carcinoembryonic antigen) antibody and perfluorotripropylamine (FTPA) was injected into a nude mouse inoculated with human colon carcinoma LS174T. Three days after the injection, in vivo fluorine‐19 chemical shift images of the spectral signals of the two perfluorocarbons (PFCs) were obtained simultaneously. The signal intensities and distributions of FMIQ and FTPA were similar in the liver and spleen but different in the tumor. FMIQ was detected in almost the entire tumor, with scattered areas of high uptake. FTPA, however, was detected only in the center of the tumor. The results suggest that F‐19 chemical shift imaging of two PFCs, one coupled to antibody and the other not, has potential application in tumor diagnosis.

📜 SIMILAR VOLUMES

Correction of chemical-shift artifacts i
Correction of chemical-shift artifacts in multislice F-19 imaging with perfluorooctyl bromide
✍ B. Özdemirel; O. Nalcioglu 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 531 KB

## Abstract Chemical‐shift artifact correction methods for multislice F‐19 imaging with perfluorooctyl bromide are described and results obtained with physical phantoms presented. Utilization of the two long‐T2 spectral peaks of PFOB in multislice imaging enhances the imaging efficiency considerabl

19F chemical shifts, coupling constants
19F chemical shifts, coupling constants and conformational preferences in monosubstituted perfluoroparacyclophanes
✍ Ion Ghiviriga; Lianhao Zhang; Henry Martinez; Rubén H. Contreras; Cláudio F. Tor 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 485 KB

## Abstract In the process of studying the chemistry of perfluoro[2.2]paracyclophanes (PFPCs), a novel class of compounds, it became necessary to identify some disubstituted products. To achieve this goal, we characterize in this work some monosubstituted PFPCs, identifying their ^19^F^19^F coupli

Characterization of the cerebral distrib
Characterization of the cerebral distribution of general anesthetics in vivo by two-dimensional 19F chemical shift imaging
✍ Palamadai N. Venkatasubramanian; Ying J. Shen; Alice M. Wyrwicz 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 639 KB

## Abstract The distribution of two fluorinated anesthetics, halothane and isoflurane, in rabbit brain was mapped during the course of their uptake using ^19^F NMR chemical shift imaging techniques. Use of a short phase‐encoding time and free induction decay acquisition minimized __T__~2~‐related s

Application of 19F chemical shift imagin
Application of 19F chemical shift imaging in studies of mice with orally administered 5-fluorouracil
✍ Hideto Kuribayashi; Yoshihiro Doi; Yoko Kanazawa 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 185 KB

## Abstract In vivo quantitative metabolic mapping is an ideal tool for pharmacokinetic studies. Oral 5‐fluorouracil (5‐FU) and its metabolites in mice were imaged simultaneously by the ^19^F fast spin echo (FSE) sequence using interleaved frequency selection at 9.4T. However, 5‐FU images in the sm

Reblurred deconvolution method for chemi
Reblurred deconvolution method for chemical shift removal in F-19 (PFOB) MR imaging
✍ H. K. Lee; Orhan Nalcioglu 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 764 KB

## Abstract Perfluorocarbons such as perfluoroctylbromide (PFOB) can be used as contrast agents in the vascular system for fluorine‐19 magnetic resonance imaging or as synthetic oxygen carriers. F‐19 imaging has been proposed for studying the vascular system, capillary flow, tissue perfusion, and t