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In vivo expression patterns of survivin and its splicing variants in chronic liver disease and hepatocellular carcinoma

✍ Scribed by Hidetaka Takashima; Tomoki Nakajima; Michihisa Moriguchi; Satoru Sekoguchi; Taichiroh Nishikawa; Tadashi Watanabe; Tatsuo Katagishi; Hiroyuki Kimura; Masahito Minami; Yoshito Itoh; Keizo Kagawa; Takeshi Okanoue


Book ID
111237289
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
915 KB
Volume
25
Category
Article
ISSN
0106-9543

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## Abstract Survivin, a novel member of the inhibitor of apoptosis protein (IAP) family, reduces the susceptibility of tumor cells to proapoptotic stimuli, thereby promoting tumor cell survival during tumor progression and treatment with anticancer drugs. Recently, we identified 2 novel alternative

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## Abstract Survivin, a member of the inhibitor of apoptosis protein family, is expressed in most human cancers, but undetectable in normal differentiated adult tissue __in vivo__. Because of this cancer‐related expression, survivin is a promising target for cancer therapy. To determine the express