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In vivo evidence for GABAA receptor changes in the sensorimotor system in primary dystonia

✍ Scribed by Valentina Garibotto; Luigi M. Romito; Antonio E. Elia; Paola Soliveri; Andrea Panzacchi; Assunta Carpinelli; Michele Tinazzi; Alberto Albanese; Daniela Perani

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 206 KB
Volume: 26
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.23553

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background:

Preclinical and clinical evidence suggests that impaired gamma‐aminobutyric (GABA) control, leading to disinhibition within the sensorimotor system, might play a role in dystonia. Aim of this study is the in vivo assessment of the GABAergic system in dystonia using positron emission tomography (PET) and ^11^C‐flumazenil, a selective GABA~A~ receptor ligand.

Methods:

Fourteen subjects with primary dystonia (9 carriers of the DYT1 mutation and 5 sporadic cases) were compared to 11 controls, using a simplified reference tissue model to measure binding potential.

Results:

Voxel‐based analyses showed a reduction in GABA~A~ receptor expression/affinity both in DYT1 carriers and sporadic patients in primary motor and premotor cortex, primary and secondary somatosensory cortex, and in the motor component of the cingulate gyrus.

Conclusions:

Dysfunction of GABA~A~ receptors in sensorimotor systems in primary (genetic and sporadic) dystonia supports the view that lack of GABAergic control may be associated with the generation of dystonic movements. © 2011 Movement Disorder Society

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