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In vivo evaluation of injectable thermosensitive polymer with time-dependent LCST

✍ Scribed by Eric Henderson; Bae Hoon Lee; Zhanwu Cui; Ryan McLemore; Tedd A. Brandon; Brent L. Vernon

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
703 KB
Volume
90A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

The focus of this study was to examine the biocompatibility, time‐dependent LCST, and bioerodable properties of a copolymer system composed of NIPAAm, dimethyl‐γ‐butyrolactone (DMBL), and acrylic acid (AAc). Sprague Dawley rats were subcutaneously injected with 25 wt % solutions of poly(NIPAAm‐co‐DMBL‐co‐AAc). At predetermined times, animals were sacrificed and polymer implants were recovered for characterization via ^1^H‐NMR. In addition, polymer‐contacting tissue sections were harvested and processed for histology. The biocompatibility of the implants was assessed by counting the number of fibroblasts and leukocytes present at the tissue‐implant interface. The LCST data obtained from the in vivo implants was shown to agree with that of in vitro findings. Implant mass was shown to decrease after 4 days, indicating accelerated diffusion rates with increased implant swelling, hydrolytic degradation was confirmed with ^1^H‐NMR measurements. The cellular presence at the copolymer implant‐tissue interface was shown to return to that of normal tissue 30 days postimplantation, which suggests a normal wound healing response. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

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