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In vivo evaluation of cholesterol as a matrix for the controlled-release of progesterone

✍ Scribed by Lee R. Beck; Suzanne L. Lowry


Book ID
115843346
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
735 KB
Volume
18
Category
Article
ISSN
0010-7824

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Sustained-release hormonal preparations
✍ A. A. Joseph; J. L. Hill; J. Patel; S. Patel; Fred A. Kincl πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 536 KB

Progesterone-sterol pellets were made that porvided a zero-order release of progesterone for 80 days. 4-(14)C-Progesterone was used to measure the release in vitro and in vivo. The dissolution rate in vitro (distilled water as the desorbing medium) for progesterone-cholesterol (59:41 w/w) and the pr