Biodegradable cystamine spacer facilitat
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Tianyi Ke; Yi Feng; Junyu Guo; Dennis L. Parker; Zheng-Rong Lu
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Article
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2006
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Elsevier Science
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English
β 449 KB
Poly(L-glutamic acid) (PGA)-cystamine-[gadolinium (Gd)-DO3A] was prepared in high yield with a high Gd-DO3A conjugation efficiency. Approximately 55% of the carboxylic groups in PGA were loaded with Gd-DO3A via cystamine as the spacer. Cystamine can be readily cleaved by endogenous thiols to release