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In Vivo Evaluation of a PAMAM-Cystamine-(Gd-DO3A) Conjugate as a Biodegradable Macromolecular MRI Contrast Agent

✍ Scribed by Xu, R.; Wang, Y.; Wang, X.; Jeong, E.-K.; Parker, D. L.; Lu, Z.-R.


Book ID
126702735
Publisher
Royal Society of Medicine Press
Year
2007
Tongue
English
Weight
295 KB
Volume
232
Category
Article
ISSN
1535-3702

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Biodegradable cystamine spacer facilitat
✍ Tianyi Ke; Yi Feng; Junyu Guo; Dennis L. Parker; Zheng-Rong Lu πŸ“‚ Article πŸ“… 2006 πŸ› Elsevier Science 🌐 English βš– 449 KB

Poly(L-glutamic acid) (PGA)-cystamine-[gadolinium (Gd)-DO3A] was prepared in high yield with a high Gd-DO3A conjugation efficiency. Approximately 55% of the carboxylic groups in PGA were loaded with Gd-DO3A via cystamine as the spacer. Cystamine can be readily cleaved by endogenous thiols to release