In vivo evaluation of a novel alginate dressing

✍ Scribed by Suzuki, Yoshihisa ;Tanihara, Masao ;Nishimura, Yoshihiko ;Suzuki, Kyoko ;Yamawaki, Yoshio ;Kudo, Hitoshi ;Kakimaru, Yoshimi ;Shimizu, Yasuhiko

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 413 KB
• Volume: 48
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(1999)48:4<522::aid-jbm18>3.0.co;2-o

✦ Synopsis

Alginate dressings are currently used in the management of epidermal and dermal wounds, and provide a moist environment that leads to rapid granulation and reepithelialization. However, a cytotoxic effect on proliferation of fibroblasts and residual material with inflammation in healing wounds have been reported recently. We have developed a new alginate dressing (AGA-100), which does not have an inhibitory effect on proliferation of fibroblasts. The purpose of this study was to evaluate the new alginate dressing with respect to wound healing in full-and partial-thickness pig wounds and with respect to biodegradation following implantation into rabbit muscle. Kaltostat and Sorbsan, both well-established commercial dressings, were used as control. The closure rate of full-thickness wounds treated with AGA-100 was significantly higher on day 15 compared with that with Kaltostat and Sorbsan. Reepithelialization rate of partial-thickness wounds treated with Sorbsan was statistically significantly lower on day 3 than those with the other two dressings. As to dressing debris remained in the healing wound, a large amount of foreign debris was noted in all the full-thickness wounds treated with Kaltostat or Sorbsan, while only about one-third of wounds treated with AGA-100 showed a little dressing debris. AGA-100 implanted into the muscle of rabbits was bioresorbed completely within 3 months. Therefore, dressing residue in AGA-100-treated full-thickness wounds might be fully absorbed in a few months. In conclusion, it is shown that our newly developed AGA-100 possesses superior properties compared with typical alginate dressings.