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In vivo electrophysiological assessment of the putative antidepressant Wf-516 in the rat raphe dorsalis, locus coeruleus and hippocampus

โœ Scribed by M. El Mansari; P. Blier

Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
344 KB
Volume
376
Category
Article
ISSN
0028-1298

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YM992 is a selective serotonin (5-HT) reuptake inhibitor and a 5-HT 2A antagonist with potential antidepressant activity. As expected from a 5-HT reuptake inhibitor, which induces an accumulation of 5-HT in the dorsal raphe, YM992 inhibited the firing activity of these 5-HT neurons (ED50: 2.0 ฯฎ 0.2