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In vivo dynamics and pathogenicity of wild-type and resistant Hepatitis B virus during long-term lamivudine monotherapy — a clinical note

✍ Scribed by Bernhard Zöllner; Albrecht Stoehr; Andreas Plettenberg; Heinz-Hubert Feucht; Matthias Schröter; Peter Schäfer; Rainer Laufs


Book ID
117769320
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
96 KB
Volume
17
Category
Article
ISSN
1386-6532

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Treatment of hepatitis B virus (HBV) with lamivudine is effective in suppressing virus replication and results in reduced inflammatory activity. However, the emergence of lamivudine-resistant mutant virus, with amino acid substitution in the YMDD motif of DNA polymerase, has been reported. We report