In vivo downregulation of M2 receptors revealed by measurement of muscarinic K+ current in cultured guinea-pig atrial myocytes
✍ Scribed by Moritz Bünemann; Bodo Brandts; Lutz Pott
- Book ID
- 111117837
- Publisher
- Cambridge University Press
- Year
- 1997
- Tongue
- English
- Weight
- 332 KB
- Volume
- 501
- Category
- Article
- ISSN
- 0022-3751
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Ca 2+ current (L-type) and inward current caused by Ca 2+ release from the sarcoplasmic reticulum and carried by electrogenic Na+/Ca 2+ exchange have been measured in cultured atrial myocytes from hearts of adult guinea-pigs using whole-cell voltage clamp techniques. The pipette solution, used for i
The effects of anti-peptide antibodies against the second extracellular loop of human M2 muscarinic receptor on transmembrane potentials and currents in guinea pig single ventricular cells were analyzed using whole-cell patch clamp technique. These effects were compared with those of the muscarinic