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In vivo development of the lethal yellow (Ay/Ay) mouse embryo at 105 hours post coitum

✍ Scribed by Gerald R. Cizadlo; Nels H. Granholm

Book ID: 104632558
Publisher: Springer Netherlands
Year: 1978
Tongue: English
Weight: 588 KB
Volume: 48
Category: Article
ISSN: 0016-6707
DOI: 10.1007/bf00127504

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✦ Synopsis

When histologically examined in utero at 105 hours post coitum embryos from AY/a x AY[a matings contained a mean (-+ SE) of 122.7 -+ 6.5 nuclei per embryo; of these, 30.2 -+ 2.4 nuclei were in the inner cell mass (ICM) and 92.5 -+ 4.8 nuclei were within trophoblast cells. Embryos from d AY/a x 9 a/a matings contained a mean of 141.4 -+ 10.6 nuclei per embryo of which 41.7 -+ 4.5 nuclei were within the ICM and 99.7 + 6.9 nuclei were trophoblastic. ICM cell numbers were significantly different between genotypes (P < 0.05) suggesting that homozygous Ay allele expression selectively interferes with ICM versus trophoblast cell differentiation during preimplantation development.

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