In vivo detection of iron and neuromelanin by transcranial sonography – a new approach for early detection of substantia nigra damage

In vivo detection of iron and neuromelan

In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage

✍ Luigi Zecca; Daniela Berg; Thomas Arzberger; Petra Ruprecht; Wolf D. Rausch; Mas 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB

## Abstract Early diagnosis of Parkinson's disease (PD) in nonsymptomatic patients is a key issue. An increased echogenicity of the substantia nigra (SN) was found previously in Parkinsonian patients and in a low percentage of healthy adults. These nonsymptomatic subjects also showed a reduced ^18^