𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo delayed rejection of tumors and inhibition of delayed - type hypersensitivity by HT-29 human colonic adenocarcinoma cell line

✍ Scribed by Gilbert J. Pommier; Françoise L. Garrouste; Dominique Bettetini; Jean M. Culouscou; Maryse M. Remacle-Bonnet

Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
654 KB
Volume
24
Category
Article
ISSN
0340-7004

No coin nor oath required. For personal study only.

✦ Synopsis

Products secreted by HT-29 human colonic adenocarcinoma cells (DMEM-HT-29) mediated strong suppressive activity of in vitro lymphoproliferative responses to several mitogens. In vivo administration of DMEM-HT-29 both inhibited the afferent limb of delayed-type hypersensitivity against the Mc FiFi2(s) syngeneic fibrosarcoma and delayed the rejection of these tumor cells by immunized animals. Transfer experiments prior or after cell fractionation did not demonstrate suppressor cells induced by DMEM-HT-29. This suggests that DMEM-HT-29 produces its effect by directly interacting with macrophage and/or T cells at the sensitization stage of the antitumor immune response.

📜 SIMILAR VOLUMES

Bile acids, non-phorbol-ester-type tumor
Bile acids, non-phorbol-ester-type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29
✍ X. P. Huang; X. T. Fan; J. F. Desjeux; M. Castagna 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 846 KB

Protein kinase C (PKC) is the target for a number of tumor promoters. The mechanism underlying the promoting effects of bile acids in colorectal cancer is not understood. We report that sodium deoxycholate (DOC) triggered activation of PKC in physiological conditions. The biphasic effects of DOC upo