𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo degradation characteristics of poly(glycerol sebacate)

✍ Scribed by Wang, Yadong ;Kim, Yu Mi ;Langer, Robert

Book ID
102872012
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
720 KB
Volume
66A
Category
Article
ISSN
0021-9304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We have developed a series of biodegradable elastomers, poly(glycerol sebacate) (PGS), based on glycerol and sebacic acid. The polymers are potentially useful in soft tissue regeneration and engineering. To evaluate the performance of PGS in a physiological environment, we compared their degradation profiles with poly(DL‐lactide‐co‐glycolide) (50:50, carboxyl ended, M~w~ 15,000) in vivo. Among the parameters examined are changes in weight and mechanical strength with time, implant geometry, surface characteristics, and degree of swelling. Unlike poly(DL‐lactide‐co‐glycolide), PGS primarily degrades by surface erosion, which gives a linear degradation profile of mass, preservation of geometry and intact surface, and retention of mechanical strength. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 66A: 192–197, 2003

📜 SIMILAR VOLUMES

Degradation behavior of poly(glycerol se
Degradation behavior of poly(glycerol sebacate)
✍ Irina Pomerantseva; Nicholas Krebs; Alison Hart; Craig M. Neville; Albert Y. Hua 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 598 KB

## Abstract Poly(glycerol sebacate) (PGS), a promising scaffold material for soft tissue engineering applications, is a soft, tough elastomer with excellent biocompatibility. However, the rapid __in vivo__ degradation rate of PGS limits its use as a scaffold material. To determine the impact of cro

Glycolic acid modulates the mechanical p
Glycolic acid modulates the mechanical property and degradation of poly(glycerol, sebacate, glycolic acid)
✍ Zhi-Jie Sun; Lan Wu; Wei Huang; Chang Chen; Yan Chen; Xi-Li Lu; Xiao-Lan Zhang; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 686 KB

## Abstract The development of biodegradable materials with controllable degradation properties is beneficial for a variety of applications. Poly(glycerol‐sebacate) (PGS) is a promising candidate of biomaterials; so we synthesize a series of poly(glycerol, sebacate, glycolic acid) (PGSG) with 1:2:0

In vitro and in vivo degradation of poly
In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers
✍ Christopher J. Bettinger; Joost P. Bruggeman; Jeffrey T. Borenstein; Robert Lang 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 408 KB

## Abstract Biomaterials with a wide range of tunable properties are desirable for application‐specific purposes. We have previously developed a class of elastomeric poly(ester amides) based on the amine alcohol 1,3‐diamino‐2‐hydroxypropane termed poly(1,3‐diamino‐2‐hydroxypropane‐__co__‐polyol seb