This study investigates the generation of primary melanoma cell-specific cytotoxic T lymphocytes (CTLs) in vitro. Induction of peptide-specific CTLs from unfractionated naive peripheral blood mononuclear cells from HLA-A2 healthy donors was assessed using 2 recently described 9-mer epitopes from the
✦ LIBER ✦
In vivo cytotoxic T-lymphocyte induction may take place via CD8+ T helper lymphocytes
✍ Scribed by J.J. Lasarte; P. Sarobe; J. Prieto; F. Borrás-Cuesta
- Book ID
- 116158144
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 910 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0923-2494
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## BACKGROUND. Most strategies in cancer immunotherapy are aimed at the induction of a strong cellular immune response against the tumor. Particularly, CD8 + T lymphocytes have been proven in multiple animal models to be critical for the eradication of solid tumors. METHODS. We used a population o