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In Vivo Cross-Linking and Immunoprecipitation for Studying Dynamic Protein:DNA Associations in a Chromatin Environment

✍ Scribed by Min-Hao Kuo; C.David Allis


Book ID
115639094
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
167 KB
Volume
19
Category
Article
ISSN
1046-2023

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Ferric nitrilotriacetate (Fe-NTA) induces renal proximal tubular damage associated with lipid peroxidation and oxidative DNA base modifications that finally leads to a high incidence of renal adenocarcinoma in rodents. In the present study, we report on the in vivo formation of DNA-protein cross-lin