In vivo characterization of the interface between cortical bone and biphasic calcium phosphate by the PIXE method
✍ Scribed by Jallot, E.; Irigaray, J. L.; Weber, G.; Frayssinet, P.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 321 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0142-2421
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✦ Synopsis
The aim of this study is to evaluate the resorption of a calcium phosphate ceramic composed of 75% hydroxyapatite and 25% b-tricalcium phosphate (HTCP) used as a biomaterial. The animal implantation has been made in the cortical femur of sheep. Delays of 2,4,8,12, 16, 20, 28, 36 and 48 weeks between graft and analysis were used. The samples were a section of cortical bone containing the implant. The mechanism of bioceramic degradation was studied by the particle-induced x-ray emission (PIXE) method. The bone/implant interface was analysed and Ca, P, Zn, Fe and Sr were measured for the nine delay periods. We found a discontinuity of elemental concentration at the interface. Thus, we observed evolution of the concentration of each element in HTCP according to time after implantation. Then we determined the kinetics of resorption.