A two-compartment disposition model of ascorbic acid (AA) pharmacokinetics with saturable and time-constrained intestinal absorption was developed. The model was fitted to pharmacokinetic data obtained after oral administration to nine healthy volunteers of two effervescent dosage forms differing in
In vivo characterization of the absorption and biotransformation of pteroylmonoglutamic acid in man: A model for future studies
β Scribed by M.D. Lucock; J. Wild; R.W. Smithells; R. Hartley
- Book ID
- 113382786
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 792 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0885-4505
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The pharmacokinetics of pafenolol, a highly selective /?,-adrenoceptor antagonist, have been studied in starved and unstarved rats. Separate groups received intravenous doses (0.3 and 3.0pmol kg-I) and oral doses (1 and 25pmol kg-I). The systemic clearance of pafenolol was constant in the dose range
The major route of biotransformation of benzoic acid and salicylic acid in man is conjugation with glycine, resulting in the formation of hippuric acid and salicyluric acid, respectively. Both processes are capacity-limited in the usual dose range and approach a maximum rate following administration