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In vivo characterization of extracellular GABA release in the caudate nucleus and prefrontal cortex of the rhesus monkey

✍ Scribed by Bhaskar S. Kolachana; Richard C. Saunders; Daniel R. Weinberger

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 112 KB
Volume: 25
Category: Article
ISSN: 0887-4476
DOI: 10.1002/(sici)1098-2396(199703)25:3<285::aid-syn8>3.0.co;2-7

No coin nor oath required. For personal study only.

✦ Synopsis

Extracellular gamma amino butyric acid (GABA) levels were measured in the caudate nucleus and the prefrontal cortex of the rhesus monkey brain using in vivo microdialysis under isofluorane gas anesthesia. Evoked GABA release was investigated for voltage sensitivity and calcium (Ca 21 ) dependency. There was a multifold increase in extracellular GABA levels following local perfusion with: (1) high potassium (50 mM, KCl), ( 2) veratridine (10 µM), and (3) the GABA releasing agent and uptake blocker, (2) nipecotic acid (1 mM). Release of GABA was significantly reduced when veratridine or (2) nipecotic acid were coinfused in Ca 21 -free cerebrospinal fluid (CSF). Coinfusion of nipecotic acid with TTX (10 µM) also resulted in attenuation of evoked GABA release. These results suggest that GABA levels recovered using in vivo microdialysis, from the caudate nucleus and the prefrontal cortex in the rhesus monkey, derive in significant part from vesicular pools and the exocytotic process is both Ca 21 -dependent and voltagesensitive.

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