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In vivo bioluminescent monitoring of chemical toxicity using heme oxygenase-luciferase transgenic mice

โœ Scribed by S.E. Malstrom; D. Jekic-McMullen; L. Sambucetti; A. Ang; R. Reeves; A.F. Purchio; P.R. Contag; D.B. West


Book ID
113923374
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
500 KB
Volume
200
Category
Article
ISSN
0041-008X

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Upregulation of heme oxygenase-1 (HO-1) has been proposed as a critical mechanism protecting against cellular stress during liver transplantation, providing a potential target for new therapeutic interventions. We investigated the feasibility of in vivo bioluminescence imaging (BLI) to noninvasively