Three 18F labeled fluoronitroimidazoles have been prepared as potential in vivo markers of hypoxic cells in tumors, and ischemic areas of the heart and brain. 1-(2-Nitroimidazolyl)-3-[18F]fluoro-2-hydroxypropanol (18F]fluoro-normethoxymisonidazole) 4, 1-(2-[18F]fluoroethyl)-2-nitroimidazole 7, and 1
In vivo biodistribution and pharmacokinetics of18F-labelled Spiegelmers: a new class of oligonucleotidic radiopharmaceuticals
✍ Scribed by Raphaël Boisgard; Bertrand Kuhnast; Stefan Vonhoff; Chéraz Younes; Françoise Hinnen; Jean-Marc Verbavatz; Bernard Rousseau; Jens Peter Fürste; Britta Wlotzka; Frédéric Dollé; Sven Klussmann; Bertrand Tavitian
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 351 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0340-6997
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Formation of islet amyloid deposits contributes to the progressive loss of beta‐cells in Type 2 diabetes. Islet amyloid is composed of islet amyloid polypeptide (IAPP). [(N‐Me)G^24^, (N‐Me)I^26^]hIAPP(22–27) peptide was found to bind human IAPP with high‐affinity and inhibit fibrillogen
## Abstract __N__‐[(1‐Ethyl‐2‐pyrrolidinyl)methyl]‐5‐(2‐[^18^F]fluoroethyl)‐2,3‐dihydroben‐zofuran‐7‐carboxamide ([^18^F]5) was synthesized __via__ nucleophilic substitution with K^18^F/Kryptofix222 complex in 5.4∼6.8% radiochemical yields with a specific activity of larger than 5.6 TBq/mmol (150 C