In Vivo Bioavailability and Metabolism of Topical Diclofenac Lotion in Human Volunteers
โ Scribed by Xiaoying Hui; Philip G. Hewitt; Nicholas Poblete; Howard I. Maibach; J. Zev Shainhouse; Ronald C. Wester
- Book ID
- 110305168
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 564 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The percutaneous absorption of diclofenac was studied in ten healthy volunteers treated with Emulgel containing 1 -16% diclofenac diethylammonium for 8 d as follows: a single application of 5 g Emulgel on days 1 and 8, and two applications d-I on days 2-7. Plasma concentration profiles of unchanged
The relative bioavailability of four monolithic enteric coated (MEC) diclofenac products was compared in 16 healthy volunteers. Only one generic product was fully bioequivalent with the reference product Voltaren with regard to AUC, C , , , and ti,,. Two products showed significant differences in tl
Sildenafil is the first oral therapeutic agent for the management of male erectile dysfunction. Its oral bioavailability is only 40% due to extensive presystemic elimination, mainly by CYP3A4. This study examined the effect of coadministration of ciprofloxacin or clarithromycin, which inhibit CYP3A4